Sothern began her career in the late 1920s in bit parts in films. In 1939, MGM cast her as Maisie Ravier, a brash yet lovable Brooklyn showgirl. The character proved to be popular and spawned a successful film series (Congo Maisie, Gold Rush Maisie, Up Goes Maisie, etc.) and a network radio series (The Adventures of Maisie).